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KMID : 0616120090400030173
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 3 p.173 ~ p.177
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Antimicrobial Property of honeybee (Apis mellifera L.) venom against Propionibacterium acnes and Aerobic Skin Flora
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Han Sang-Mi
Lee Kwang-Gill
Yeo Joo-Hong
Kim Wan-Tae
Park Kwan-Kyu
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Abstract
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The in vitro antibacterial activities of honeybee(Apis mellifera. L) venom collected by a bee venom collector were investigated against several bacteria including antibiotic-susceptible and resistant Propionibacterium acnes. Honeybee venom was prepared with different concentrations and they showed strong antibacterial activites. Honeybee venom inhibited the growth of the tested antibiotic-resistant P. acnes at the concentration of 1 mg/ml. The inhibitory activities of the honeybee venom showed time-dependent manner. Honeybee venom did not influence the viability of human dermal fibroblast at the high concentration of less than 10 mg/ml. From these results, we expect that honeybee venom has strong antibacterial activities and has advantage for treating cure.
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KEYWORD
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Bee venom, acne, Propionibacterium acnes, Antibacterial activity
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